منابع مشابه
PDZ domain polarity complexes
a member of the group, said they used 58 embryos to generate three stem-cell populations, but two were lost at an early stage. But he said this was fewer embryos than was used by other groups and attributed the success to the use of donated embryos that had been screened for genetic disorders, rather than discarded embryos from in vitro fertilisation procedures which may not be of sufficient qu...
متن کاملPDZ domain proteins: Scaffolds for signaling complexes
InaD, a Drosophila photoreceptor scaffolding protein, assembles multiple signal-transducing proteins at the membrane via its five PDZ domains, enhancing speed and efficiency of vision. Extensive conservation of PDZ domains suggests that these motifs have a general role in organizing diverse signaling complexes.
متن کاملDiscs Lost, a Novel Multi-PDZ Domain Protein, Establishes and Maintains Epithelial Polarity
Polarization of epithelial cells depends on a hierarchical process whereby specific membrane-associated proteins become targeted to specialized membrane domains. Here, we describe a novel Drosophila protein, Discs Lost (DLT), that plays a crucial role in the polarization of embryonic epithelia during cellular blastoderm formation. At subsequent stages of development, DLT interacts with the apic...
متن کاملApicobasal polarity complexes.
Asymmetric distribution of proteins and other molecules within cells leads to cell polarization. One of the most studied examples occurs in epithelial cells that polarize to form apical and basolateral surfaces (Nelson, 2003). Although we know much about directed protein trafficking after cells are polarized, less is known about the initial mechanisms that lead to polarization. Genetic and bioc...
متن کاملOrigins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain.
The LAP (leucine-rich repeat and PDZ-containing) family of proteins play a role in maintaining epithelial and neuronal cell size, and mutation of these proteins can have oncogenic consequences. The LAP protein Erbin has been implicated previously in a number of cellular activities by virtue of its PDZ domain-dependent association with the C termini of both ERB-B2 and the p120-catenins. The pres...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2003
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(03)00599-2